I didn't play 10, but gosh, I love this game. I think the main difference between 10 and 11 is that they overhauled the draft system, but the features list also says that they added owner personalities (my owner as the Brewers is generous, but demands a lot) and added FIP, ERA+, and UZR.
We should start an OOTP thread. I'm just dying to share my team with people. My rotation has Greinke, Gallardo, and Cliff Lee, and they aren't even my ace.