On a Wednesday evening, driving to the game from Frederick will be hellish. I would drive to Shady Grove Metro and avoid the nightmare. Metro isn't perfect, but 270/Beltway/GW Parkway/395 is a nightmare after, say 3:30 or 4:00.
I'm in Gaithersburg. This is my territory. Message me if you want.
Apple Maps shows that it's about a 90 minute trip, so realistically, 2 hours to 2:30. I'd still drive versus taking the train.
