only 2 issues are roster-related, but Janes discussing 4 issues: CBA negotiations, universal DH, Bauer, and standardizing the baseball.
https://www.washingtonpost.com/sports/2022/01/01/mlb-big-questions-2022/She points out that Manfred in the middle of December said non-economic issues are off the table until the CBA is worked out. What this may mean is that there may not be much time to work out whether there will be a DH in the NL if the CBA negotiations go into the spring. Even if there were a quick agreement outside the CBA, would there be enough time for NL teams to chase potential DHs. You'd think guys like Castellanos would be impacted, and of course RZ.
The baseball itself is an issue. Apparently, there was a mid-season switch of baseballs that was not told to the players or the public. The original baseball was supposed to fly less to get more action / balls in play. My sense is the offense was down so much early on that they made the switch. The article discusses switching to a tackier ball to allow for better pitcher grip, similar to Japan.
