Since the rule 5 draft changed, not many guys make a difference at the ML level. Sure it could happen but the chances are slim.
We have a really good ML team. Rizzo and his staff really need these next few drafts to replenish the farm system.
Our starters of Werth, Harper, Span (Goodwin to replace him hopefully in 14' or 15'), Zim, Desi, Espi, Suzuki/Ramos and hopefully ALR/Tyler Moore should be in place for the next several years. The rotation is pretty well set.
If Rizzo can rebuild that system over the next 2-3 years then we should be fine. That is of course assuming those starters all stay fairly healthy long term.