For me, sure. I can play song from my Nook Color (Android), travel without wasting hard drive space on a laptop, and access from each computer. I simplifies the file synchronization. I have a Diskstation at home with a few TBs storage but even though it streams to iTunes this is just easier. Granted I am assuming that at some point the uploading process will be complete therefore becoming less burdensome and that the interface will be get better. Very plain Jane UI right now, not easy to use, just limited.
For me, Youtube or Mediafire just don't cut it.