Brady versus Big Dick Nick. Almost 900 yards passing between the 2.
In terms of QB performance, that and the shootout with Jake Delhomme were 2 of the 3 best Brady games in the SB, along with the Matt Ryan game, but in terms of profile matchups, neither Delhomme nor Nick Foles had the HOF / MVP / High QB rating hype of, say Brady - Wilson. For all the talent on the field at QB, Brady Warner wasn't hyped at the time as a match up, and the Brady Eli / Brady McNabb / Brady Goff games were less offensive showcases than great defense.
Which game did I miss? Warner, Delhomme, McNabb, Eli, Eli, Wilson, Ryan, Foles, and Goff. I think I got them all.