if your wife is still suffering like this middle of next week, talk to the doc again. Some meds don't work right for some people. Also, some need a week or so to build up in your body. Zoloft is a wonderful one as it starts working immediately and doesn't have as much of that "build up" time. However, prozac, etc. do. Personally, I don't like those as much as Zoloft. That's a great med for Andrew and me!
You're right about keeping on talking to her. A couple of visits w/ a counselor could help too if the medicine doesn't seem to help much.