Most 2 coloured cats are male I think.
Calico cats (orange, white, black patches) and tortoiseshell (black and orange) are almost 100% female. In 15 years of working at an animal shelter I never saw a male calico or tortie. Orange tabbies (orange stripes) are male about 80% of the time. Other colors tend to skew more evenly between genders.
And those are your useless facts of the day.