Nothing really but I guess the main thing is to make sure your family is left with enough money. I mean, 10 mil is perfect amount but 250 mil is even better. Now when you're in the double digit billions then there's no point... Which is why Bill Gates is the man for giving most of his money up for research and such.
I'm not sure what Pujols could really do with $250m instead of say $200m, unless he really planned to eradicate hunger or some grandiose charitable effort.
As far as having enough to live on, and live well, there really is no difference.