Chuck Yeager on Science Friday just now...he said that sending a human on the 4-month trip to Mars is a big waste of time and money
After spending 23 hours on planes yesterday, I really can't imagine how the Mercury astronauts didn't go mad in that little capsule.
I guess this stuff doesn't make the news... But they just announced this very week the two guys who will spend one entire year on the ISS to study the effects of these very types of trips. One of whom is the brother of Congresswoman Giffords, who himself was an astronaut. Scott Kelly I believe is the one going up for a year. Makes you realize what a exclusive, unopened club NASA astronauts are.