The problem is getting ahead in the count. Out of 20.216 pitches, only 3,801 (19%) have been from behind in the count. He's the kind against which you need to open up the hitting zone a bit and be more aggressive. If you try to wait him out, you're K'd.
He has one of the best scatter diagrams of pitch locations we'll ever see.
That's very true. Also, he uses that devastating change-up more with two strikes, so you really don't want to get to that point in the count. You can almost forget about waiting for a mistake up high, as well.