House battles a new case every week but they do a great job of adding in storylines that span several episodes which keep the show fresh.
Just about to post about House, M.D. ... it's my new favorite show. Ever since the show came out, I'd watch a few episodes here and there, but I've finally sat down and really gotten into it ... I'm hooked.
It actually reminds me a little bit of Life. The main character really draws you in and his sidekicks are pretty solid as well. Two beautiful women anchor the shows (Dr. Cameron in House, Detective Reese in Life). The episodes open up with a problem, there's some turbulence along the way then the hero saves the day (or doesn't). If you like House, I really think you'll enjoy Life.