On MLB Network they said that Manuel will lose the protest. The rule in MLB is different than the rule in the NFL. In the NFL, if you are reviewing a call, and notice another mistake (like a holding on a catch / no catch call), you cannot overturn the call on the new basis. In MLB, everything you see on the camera shot is fair game for reversal. As long as Joe West (yes, Joe West) says he was reviewing to see if the ball struck the yellow line or was in the stands, he can call the fan interference and he can't be reversed.