I'm looking at a climb like that on my commute. I'm thinking of walking it for a while.
Made a dry run of my commute to the Mark Center on 2 wheels this AM. At ~11 miles and slightly more than an hour, it's quite doable. Howver, that uphill run from the exit from the Holmes Run Trail up Beauregard to Reading is rough - its a 150' climb in 2/3 of a mile.