I'm going to say a big no to Desmond as a lead off guy. He is a slugger and there is no reason to waste his power when we have no one on base. I'd say our best lead off option right now would be a Lombo/Espinosa platoon at second.
Lombo/Espy
Harper
Zim
Laroche/Moore
Morse/LaRoche
Moore/Morse
Desmond
Florse
Yeah, I don't even see how Desmond's biggest fanboi could think that him batting leadoff would be good for anyone.