I actually took one of those bus tours in 2010 which has its pros and cons. Pro was we saw SO much: Rome, Venice, Florence, Pisa, Sienna (in Tuscany), Asisi, Gandolfo, several other smaller places that I can't think of right now that were just gorgeous so we got a lot of bang for our buck. The drawback was that you had very limited time in each area and Ali's right, you could spend the whole vacation in Rome and be entertained every second. I really wanted to see as much as I could of the entire country so that's why we opted for the bus trip but if you know there are just a couple of areas you want to see doing it yourself so you could spend as much time as you wanted at each place would probably be best. I will say it was easily my favorite place I ever visited, I had wanted to go my whole life and I was not disappointed.