Forgot to mention, I'm in the 2011 season of my franchise now. I won the World Series in 2010... here's what my team currently looks like (I made a ton of trades in the offseason):
C Matt Wieters, 1B Adam Dunn, 2B Howie Kendrick, 3B Ryan Zimmerman, SS Ian Desmond, LF Adam Lind, CF Andrew McCutcheon, RF Nelson Cruz. SP: Rich Harden, Scott Feldman, John Lannan, Stephen Strasburg, Ross Detwiler. Pen: Daniel Bard, Frank Francisco, Kyle McClelland, Sean Burnett, Tyler Clippard, Brian Bannister.
I am playing on All-Star now, which is much harder, but I moved the base-stealing ones back to Pro (stealing is impossible as it is), and batting is right about in the middle between Pro and All-Star. Left the pitching and CPU sliders (CPU got a ton better). I'm like .500 right now.
One notable thing: I had a perfect game going on opening day with Rich Harden against the Phillies, nearly won a million bucks (is that thing still going?)... Ryan Howard hit a HR to lead off the 8th. 7 perfect innings, and I lost the game!