For the first month, the Nationals play the Twins, Marlins, Phillies, Braves, and then a three game series against the Cards. That's basically 22 games against poor teams.
It's bullcrap if you think games in April don't matter. The Nationals have to set the tone early against the scrubs of the NL East. If they go in to May with anything less than a 16-8 record, they can kiss the playoffs goodbye.